IL1B and colorectal cancer: A Caucasian-Danish prospective case-cohort study showed that variant genotypes of IL1B SNPs rs4848306 (− 3737C>T) and rs1143623 (− 1464G>C) were associated with colorectal cancer risk [dominant model: IRR (95% CI) = 0.81 (0.68–0.97), P = 0.02; dominant model: IRR (95% CI) = 1.22 (1.04–1.44), P = 0.02]10.