Through IRS1, PTPN11, and RAC1 as well as TP53, SP1, CCND1 and XPO1 connections, several major pathways including renal cell carcinoma, viral carcinogenesis, cell cycle, FoxO signaling, pathway in cancer, NK cells mediated cytotoxicity, Ras signaling pathways were implicated as key molecular pathways associated with NDV persistent infection in EJ28 cells. The gene discussed is PTPN11; the disease is hereditary clear cell renal cell carcinoma.