By modular analysis of the PPI network of persistent TCCSUPPi cells, the RPL8 node group was upregulated and implicated in the pathways of bladder cancer, malaria, mitophagy, p53 signaling, ECM-receptor interaction, TGF-beta signaling, phagosome, ribosome, focal adhesion and proteoglycans in cancer were clustered in the same module, suggesting that these genes co-function together to develop NDV persistent infection in the TCCSUP bladder cancer cell line. The gene discussed is TP53; the disease is urinary bladder carcinoma.