As illustrated, pathways of bladder cancer, malaria, mitophagy, p53 signaling, ECM-receptor interaction, TGF-beta signaling, phagosome, ribosome, focal adhesion and proteoglycans in cancer were significantly enriched (p < 0.05) in the upregulated DEGs in the nodes connecting the PPI network (subnetwork 1) (Supplementary Table S1). The gene discussed is TP53; the disease is cancer.