These five modules have been identified as significantly (p < 0.05) acting together to contribute towards the development of NDV persistent infection in EJ28 bladder cancer cells; by virtue of their functionally connections via the upregulation of EP300, IRS1, PTPN11, and RAC1and downregulation of TP53, SP1, CCND1 and XPO1 respectively. This evidence concerns the gene EP300 and urinary bladder carcinoma.