Notably, nine of the 23 CpGs with significant marginal effects on psychomotor skills at 3 years also overlapped with common trajectory CpGs, annotated to RFTN1, ERV3-1, RBM39, DYRK2, GABPA, ATP5J, FAM45A, FAM45B, RNASEH2C, and PPP1R12B. As described, several of these genes are implicated in development (e.g., DYRK2 [72] and TGFB [78]), neuronal differentiation (GABPA [70]), and neurological phenotypes, including ADHD (RNASEH2C [73], PEX10 [26, 44, 76], and SHANK2 [77]). Here, SHANK2 is linked to attention deficit-hyperactivity disorder.