Most of the upregulated genes in SCZ and BD codify for mRNAs that are primarily transcribed during the promyelocytic (DEFA1, ELANE, CEACAM6, CTSG, MPO, MS4A3) and myelocytic (BPI, OLFM4, LTF, HP, LCN2, CAPM, CEACAM8) stages of neutrophil differentiation, suggesting that the immature neutrophils described here represent a heterogenous population composed primarily of promyelocytes and myelocytes [49]. This evidence concerns the gene CTSG and Behcet disease.