Retinitis pigmentosa (RP) is a genetic disorder causing irreversible “night blindness.” However, animal models do not fully recapitulate severe forms of the disease, such as X-linked RP (XLRP), caused by mutations in RP2. Animal models for this disease display mild phenotypes, whereas humans exhibit macular atrophy in childhood in some extreme cases. This evidence concerns the gene RP2 and retinitis pigmentosa 1.