DNAJC6 and Parkinson disease: hESC-derived midbrain organoids that carry a loss-of-function mutation in DNAJC6, a gene associated with early-onset PD, have been shown to recapitulate PD pathology, exhibited defects in midbrain dopamine neuron development, and revealed LMX1A (LIM homeobox transcription factor 1 alpha) as a central factor in DNAJC6-mediated PD.30