Whether secretion of growth factors (TGFβ, GAS6, FGF5 and HGF), cytokines and chemokines (IL-6, CXCL9) from CAFs,32 may affect aggressiveness and thereby associate with recurrence of endometrial cancer, is not known and could be investigated in future studies. The gene discussed is TGFB1; the disease is endometrial cancer.