VIM and cancer: Unfavorable prognosis in relation to lower vimentin expression in tumor epithelial cells may be tissue specific considering higher epithelial vimentin expression usually is linked to EMT and metastases in cancer.43, 44, 45 To further investigate whether low expression of vimentin can have clinical importance in endometrial cancer, we evaluated vimentin expression by IHC in pre-operative lesions from 518 endometrial cancer patients, including all types and grades.