TMEM106B has been recently involved in many other neurodegenerative diseases, including FTLD-C9ORF72 (5–8), amyotrophic lateral sclerosis (9), Parkinson’s disease (10), Alzheimer’s disease (11), and limbic-predominant age-related TAR DNA binding protein-43 (TDP-43) encephalopathy (12). Here, TMEM106B is linked to early-onset autosomal dominant Alzheimer disease.