Moreover, some significant genes within these empirically significant enriched pathways have been previously associated with pain problems (e.g., the PTGS2 gene (S3A and S8A Tables) [49]; the HLA-A gene (S3A and S8A Tables) [50]) and anxiety symptoms (e.g., the SYNGAP1 gene (S3B and S8B Tables) [51]; the ULK4 gene (S3B and S8B Tables) [52]). The gene discussed is PTGS2; the disease is Anxiety.