FOXO3 and Anxiety: Moreover, some significant genes within these nominally significant overlapping pathways have been previously associated with pain problems and/or anxiety symptoms (e.g., the ZNRD1 gene (S4 Table) [43]; the MDK gene (S4 and S9 Tables) [44]; the FOXO3 gene (S4 Table) [45]; the COMT gene (S9 Table) [46, 47]; the NFATC4 gene (S7 and S9 Tables) [40, 48]).