BPIFA1 and cystic fibrosis: Several serum markers have been reported to be changed at CF pulmonary exacerbation, such as caloptrectin [20], Short Palate Lung Nasal epithelium Clone 1 (SPLUNC1) [21], inflammatory markers like IL-8, C-reactive protein and neutrophil elastase antiprotease complexes (NEAPC) [22], and procalcitonin [23].