NF1 and neoplasm: Given that the patients with NF1 type microdeletion syndrome, frequently showing the lost or disruption of SUZ12, are more susceptible to tumor development, further studies on selected and larger cohorts of NF1 microdeletion patients, with a severe tumor phenotype, could shed light on the role of the members of PRC2 complex in tumor susceptibility in neurofibromatosis type 1, allowing the identification of therapeutic targets that can contribute to effective treatment.