RNF135 and neoplasm: The significant and tendential gene expression reduction of tumor suppressors TP53 and PTEN in patient 171, normally induced by RNF135 [8], is consistent with the reduced wild-type transcript and strongly indicates that the chimeric gene loses the normal function of RNF135. Instead, 5 out of 7 PRC2 target genes analyzed show a statistically significant decrease in expression levels, in patient 171 compared to healthy controls, highlighting an increased activation of the PRC2 repressive complex, that led us to hypothesize a gain-of-function modification of the RNF135-SUZ12 chimera.