Interestingly, mutations in the TRiC subunits CCT4 and CCT5 are associated with hereditary sensory neuropathies (37,38) implicating that dysfunction of TRiC in axons from lyso-Gb3 exposure could be a contributor to the peripheral neuropathy observed in FD. The gene discussed is MARVELD2; the disease is hereditary sensory and autonomic neuropathy.