Necroptosis is the first form of programmed necrosis described with a prominent role in multiple physiological and pathological conditions.[5–7] The core of the necroptosis machinery is constituted by RIPK1, RIPK3, and MLKL.[8] The exact effect of necroptosis on tumors is complex and controversial.[8,9] Indeed, several studies suggest its involvement as a cancer suppressor that participates in cancer inhibition by activating markers involved in regulated necrosis pathways, while others as cancer promoters by inhibition of tumor immunity and activation of inflammation.[10,11]. The gene discussed is RIPK3; the disease is cancer.