FOXM1 and glioblastoma: For example, the transcription factor NBAT-1NRSF/REST, which activates neuronal specificity, promotes the invasiveness of nerve GBM.[24] Foxm1-as promotes the interaction between ALKBH5 and FOXM1 mRNA and the demethylation of FOXM1 mRNA and enhances the self-renewal and tumorigenesis of GBM cells.[25]