C8orf34 and osteoarthritis: These genes functionally link to chondrogenesis (SOX genes family)73; cartilage,148 osteoarthritis,111 and lumbar disc degeneration (CCDC26/GSDMC)8; and nociceptive pathways (DCC).145 However, the function of some genes/loci (eg, C8orf34) and how they are involved in back pain are still unexplained.