Notably, their discovery of the interactive secretome between tumour cells and AM-like TAMs in this model, through cholesterol-regulating Niemann–Pick C2 protein and CC chemokine receptor 1 (CCR1) ligands, directed their current study investigating pro- and anti-tumourigenic effects of statins (Kamata et al., 2022). This evidence concerns the gene CCR1 and neoplasm.