CD226 and neoplasm: Another mechanism involves binding to MHC class I-related chain A/B (MICA/B), UL16 binding protein (ULBP), and polyoma virus receptor (PVR) on tumor cells through DNAX accessory molecule 1 (DNAM1) and natural killer cell receptors (NKRs), NKG2D, NKp30 and NKp44 on yδ T-cell membranes66,67.