MARCO has been linked to atherosclerosis, both experimentally and epidemiologically.[48, 49] As a member of the class A scavenger receptor family, MARCO can bind to the modified LDL and VLDL.[50, 51, 52] Thus, MARCO promotes lipoprotein and cholesterol deposition in artery walls, and promotes the formation of atherosclerotic plaque.[39, 53] Also, as a well‐known M1 macrophage marker, MARCO upregulation activates phagocytosis and increases lipid uptake in macrophages,[54] which converts macrophages into foam cells. Here, MARCO is linked to atherosclerosis.