WEE1 and neoplasm: Similarly, metformin (Met) is used in the treatment of type 2 diabetes as a first‐line drug, and exerts immunomodulatory effects by activating adenosine 5′‐monophosphate (AMP)‐activated protein kinase (AMPK).[9] M2‐like tumor‐associated macrophages (TAMs) are immunosuppressive cells that suppress T‐cell function directly or indirectly, ultimately promoting tumor growth.