As shown in Figure 9(a), there were 23 kinds of cell clusters in CRC patients, which were mainly divided into B cells, CD4+/8 + T cells, dendritic cells (DC), fibroblasts, mast cells, endothelial cells, macrophages, epithelial cells, monocytes, and plasma cells (Figure 9(b)), according to the expression level of marker genes (Figure S2). This evidence concerns the gene CD4 and colorectal carcinoma.