The inflammatory status of patients with CRC undergoing adjuvant therapies decreased after a total parenteral nutrition (TPN) O3FA supplementation (TNF-α, MD = -1.26, 95% CI: 2.25 to -0.27, <i>p</i> = 0.01, <i>I</i> <sup><i>2</i></sup> = 4%, <i>n</i> = 183 participants). Here, TNF is linked to colorectal carcinoma.