According to the effect of LBP on the macrophage phenotype and results from previous studies on STAT1 and STAT6 pathways involvement in IBD progression (Lim, 2011; Salas et al., 2020; Tian et al., 2021), we speculate that LBP might affect macrophage polarization through the STAT1 and STAT6 pathways to protect against IBD. This evidence concerns the gene STAT1 and inflammatory bowel disease.