STAT6 and colitis: We had demonstrated in vitro that LBP regulated M1/M2 macrophage polarization by modulating the STAT1 and STAT6 pathways, and also found that LBP could regulate macrophage polarization in DSS-induced colitis mice by the detection of the expression of M1 or M2 marker in colon tissue (Figures 1H–J; Figure 2).