According to the effect of LBP on the macrophage phenotype and results from previous studies on STAT1 and STAT6 pathways involvement in IBD progression (Lim, 2011; Salas et al., 2020; Tian et al., 2021), we speculate that LBP might affect macrophage polarization through the STAT1 and STAT6 pathways to protect against IBD. The gene discussed is LBP; the disease is inflammatory bowel disease.