The second pathway is pathways in cancer, signal transducer and activator of transcription 3 (STAT3) mediates many cancer-related signaling pathways and has an important role in immunomodulation against cancer and tumors (Zou et al., 2020), while it is also involved in promoting M2 polarization in renal macrophages, suppressing inflammatory responses, regulating immunity, and reducing RIRI (Chen et al., 2021; Liu et al., 2021d). The gene discussed is STAT3; the disease is cancer.