Finally, although HAE-C1INH is a genetic disease, mutational analysis of Serping1, the gene on chromosome 11 that encodes for C1INH, is usually not necessary apart from, in rare cases of doubt, prenatal (chorionic villous sampling or amniocentesis) or preimplantation diagnosis of HAE and scientific purposes (1, 10, 39–43). This evidence concerns the gene SERPING1 and hereditary angioedema.