The COL23A1 gene can be used as a surrogate marker for monitoring disease activity in ulcerative colitis and Crohn’s disease (Manon-Jensen et al., 2021), as well as a biomarker for papillary thyroid cancer (Pan et al., 2021) and clear cell renal cell carcinoma (Xu et al., 2017). The gene discussed is COL23A1; the disease is clear cell renal carcinoma.