The KEGG pathways were mainly concentrated in: Leishmaniasis, Pathways in cancer, HIF-1 signaling pathway, p53 signaling pathway, Salmonella infection, Small cell lung cancer, IL-17 signaling pathway, MicroRNAs in cancer, Chagas disease (American trypanosomiasis) and Amoebiasis (Figure 3D). The gene discussed is HIF1A; the disease is amebiasis.