DPYSL5 and early-onset autosomal dominant Alzheimer disease: No studies have reported behavioral defects related to NDDs in Dpysl5 mutant animal models but Lin et al., demonstrated that the hippocampal overexpression of DPYSL5 triggers social interaction deficits in both control mice and in 3xTg-Ad mice, a classical mouse model of Alzheimer’s disease (Lin et al., 2019) suggesting that DPYSL5 closely controls social behavior.