The CB1R mechanism of action is similar to the MOR to reduce the neuron’s ability to depolarize (Pertwee et al., 2010; Merighi et al., 2012) and lends itself that selective, central CB1R activation could induce respiratory depression (Doherty et al., 1983; Schmid et al., 2003; Alon and Saint-Fleur, 2017). This evidence concerns the gene OPRM1 and respiratory depression.