Recent publications have shown an opposing role of central versus peripheral CB1R activation, with coadministration of the peripherally restricted CB1R agonist, PrNMI, and morphine, morphine-induced respiratory depression was completely prevented, while administration of the brain penetrant CB1R agonist, AM356, alongside morphine enhanced the already seen respiratory depression (Wiese et al., 2021). The gene discussed is CNR1; the disease is Respiratory insufficiency due to muscle weakness.