It has also been suggested that respiratory depression resulting from CB1R activation may involve peripheral arterial chemoreceptors; other studies have reported a protective benefit from peripheral CB1R activation (Wiese et al., 2021) leaving future studies to fully parse out the role of the peripheral CB1R. Expression of CB1R within the carotid body implicates a role for blood flow regulation thereby affecting respiratory control. This evidence concerns the gene CNR1 and Respiratory insufficiency due to muscle weakness.