The most common, and well known organic cannabinoid is Δ9-tetrahydrocannabinol (THC), a mixed CB1R/CB2R partial agonist (Makriyannis, 2014; Nikas et al., 2015), that does not cause respiratory depression (Tree et al., 2010), and has been shown to be beneficial in the treatment of chronic pain, migraines, anorexia, nausea, just to name a few (Wills and Parker, 2016; Yuill et al., 2017; Wiese and Wilson-Poe, 2018; Mohammed et al., 2020). This evidence concerns the gene CNR1 and respiratory depression.