Hence, we performed this retrospective study to evaluate the effects of LH hypersecretion on the clinical outcomes of PCOS patients with letrozole-induced ovulation in intrauterine insemination (IUI) cycles, to provide a perspective on the prognostic role of elevated LH in infertile PCOS women who are scheduled for ovulation induction and to provide evidence regarding whether it is necessary to preabate LH secretion by OCs. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.