As a multisystem disease, PCOS is characterized by hypothalamic–pituitary-ovarian axis dysfunction and metabolic disturbances, such as hyperandrogenaemia, hyperinsulinaemia/insulinaemia, elevated absolute levels of circulating luteinizing hormone (LH) and its relationship to follicle-stimulating hormone (FSH) levels and chronic anovulation (3, 4). This evidence concerns the gene PLOD1 and polycystic ovary syndrome.