The subsequent multivariable analysis revealed that antepartum albumin [OR = 0.92, 95% CI (0.86–0.99)], ART [OR = 1.81, 95% CI (1.08–3.03)], HDP [OR = 2.03, 95% CI (1.06–3.91)], placenta previa [OR = 28.15, 95% CI (7.95–99.76)], PAS [OR = 4.97, 95% CI (1.85–13.32)], intrapartum CD [OR = 2.48, 95% CI (1.40–4.37)], and EFW of twins were significantly related to PPH in the overall cohort. This evidence concerns the gene ALB and placenta praevia.