We found no difference in plasma VIP between eCHA (n = 14) (3.764 ± 6.976 pmol/l, IQR 1.90–28.00), eCHR (n = 15) (4.023 ± 5.291 pmol/l, IQR 1.90–20.00), cCH (n= 15) (9.633 ± 12.01 pmol/l, IQR 1.90–35.25), and a historical group of people with migraine outside of attacks (n = 19) (11.08 ± 15.20, IQR 1.60–64.95) (p = 0.1161). The gene discussed is VIP; the disease is migraine disorder.