Thus, interfering with the NGF/proNGF balance can lead to neurodegeneration, suggesting a vicious cycle linking NGF dysmetabolism and Alzheimer’s disease (Capsoni and Cattaneo, 2006; Florencia Iulita and Claudio Cuello, 2015; Cuello et al., 2019). The gene discussed is NGF; the disease is early-onset autosomal dominant Alzheimer disease.