In the past, the study of these models showed that interfering with the NGF/proNGF balance can lead to neurodegeneration, suggesting a vicious cycle linking NGF dysmetabolism and Alzheimer’s disease-like neurodegeneration (Capsoni and Cattaneo, 2006; Florencia Iulita and Claudio Cuello, 2015; Cuello et al., 2019). This evidence concerns the gene NGF and early-onset autosomal dominant Alzheimer disease.