NGF and Down syndrome: This is of particular relevance for our study since changes in the ratio of proNGF/NGF can be found not only in AD11 mice but also in Alzheimer’s disease and in Down’s syndrome patients who develop AD with aging (Capsoni and Cattaneo, 2006; Florencia Iulita and Claudio Cuello, 2015; Cuello et al., 2019).