In addition, “antioxidant properties” and “localization to the dopaminergic nervous system” of PON2 protein mean that it may be related to both the oxidative stress hypothesis and the dopamine hypothesis, which are the major pathophysiological hypotheses of schizophrenia, and may attract attention to PON2 protein as a new research/therapeutic target. The gene discussed is PON2; the disease is schizophrenia.