lncRNA activated by TGF-β (lnc-ATB) acts as a key regulator of TGF-β signaling pathway and promotes Trastuzumab resistance and invasion-metastasis cascade in breast cancer by competitively biding miR-200c, up-regulating ZEB1 and ZNF-217, and then inducing EMT (86). The gene discussed is TGFB1; the disease is breast cancer.