The authors identified lncRNA transcription factor homeobox B13 (HOXB13) as an upstream regulator of HOXA11-AS and demonstrated that HOXB13/HOXA11-AS axis regulates the production of CCL2/CCR2 cytokines and integrin signaling in bone metastatic prostate cancer cells, while HOXA11-AS secreted from PC3 cells modulates CCL2/CCR2 cytokine signaling in osteoblasts present in the bone marrow. Here, CCL2 is linked to prostate cancer.