Numerous lncRNAs function as oncogenes in different types of cancer: NEAT1 has been reported function as oncogene in breast tumours, endometrial carcinoma and osteosarcoma (39–41); HOTAIR promotes tumorigenesis by inducing the triggering of EMT and the stemness acquisition (42); antisense non-coding RNA in the INK4 locus (ANRIL) induces tumor invasion and progression and participates to the epigenetic silencing of p15 and p16, two-tumor suppressor (43). Here, CDKN2A is linked to osteosarcoma.