As Figure 6 shows, patients with IgG-IA and IgE-IA, whether containing other subclasses or not, had the lowest frequency of hypoglycemia (Figure 6A; 16.21%, 6 of 37 cases) and the highest frequency of injection-site reactions (Figure 6B; 24.32%, 9 of 37 patients). The gene discussed is IGHE; the disease is Hypoglycemia.