RAG1 and Ataxia: In addition, previous studies reported that in Rag1 -/- mice in which EAE was induced by a transfer of in vitro differentiated MOG53-55-specific Th17 cells, systemic blockade of α4 integrins inhibited Th17 migration into the spinal cord parenchyma, but not the brain inducing signs of atypical EAE with ataxia and hemiparesis.