The most common pemphigus variants are pemphigus vulgaris (PV) characterized by autoantibodies against Dsg3, affecting the mucosa only or against Dsg1 and Dsg3, affecting the mucosa and epidermis and pemphigus foliaceus (PF) characterized by autoantibodies against Dsg1, affecting the epidermis exclusively (3–5). This evidence concerns the gene DSG3 and pemphigus.