HSPG2 and pemphigus: Because inhibition of CRAC did not show any protective effect on 2G4-mediated loss of cell adhesion, we conclude that Ca2+-influx by this mechanism does not play a major role in pemphigus pathogenesis, which is different to the anti-Dsg1-induced Ca2+signalling, which reduced cell adhesion via PI4K, PLC, IP3R and CRAC (51).