DSG3 and pemphigus: The fact that 2G4 induces the typical hallmarks of pemphigus pathology despite being directed against the EC5 domain is interesting because antibodies against most other domains than EC1 or EC2 and particularly those targeting the EC5 domain of Dsg3 or Dsg1, were reported to be mostly non-pathogenic (32, 34, 35, 64).