KEGG enrichment analysis showed that pathways in cancer (ko05200), Th17 cell differentiation (ko04659), PPAR signaling pathway (ko03320), Hippo signaling pathway (ko04392) and axon guidance (ko04360) were the top five enriched KEGG pathways in S4383-0-G vs R4345-0-G (Figure 4A, Supplementary Table S4). The gene discussed is PPARA; the disease is cancer.