HAVCR2 and Miyoshi myopathy: At diagnosis, the combination of PD-1 and TIM-3 blockade allows a partial recovery of Vγ9Vδ2 T-cell immune effector functions; in the remission phase, single PD-1 blockade is moderately effective, whereas PD-1 and LAG-3 blockade is the only combination to be minimally effective in relapsed MM (30).