IFNG and cancer: The antitumor activity of Vγ9Vδ2 T cells encompasses: 1) direct killing of cancer cells through granzyme B (GzmB) and perforin (Prf) secretion; 2) antibody-dependent cellular cytotoxicity (ADCC) dependent on CD16 expression; 3) Fas/FasL-mediated cell death; 4) production of cytokines like IFNγ and TNFα; 5) interactions with other TME-resident immune cells (25, 48, 56, 57).