Importantly, a decrease of CD4 T-cell counts was detected according to anemia severity (without anemia: 110 cells/μL [50-162]; mild: 69 cells/μL [23.8-140]; moderate: 57 cells/μL [25.5-120]; severe: 42 cells/μL [17-101]; p<0.001) (Supplementary Figure 1B). This evidence concerns the gene CD4 and anemia.