Since our previous experiments have shown that LmTLR14d is structurally conserved and has an important function in the innate immune response against bacterial infection, we questioned which adaptor-dependent pathway does LmTLR14d mediate immune response.MyD88 and TRIF are known to be important adaptor proteins in the TLR-mediated immune signaling pathway (45). Here, MYD88 is linked to bacterial infectious disease.