As shown in Figure 6B, the two doses of 103, or 102 of IL-6 Tg-PbANKA/LISP2 SPZ (group 2 and group 3, respectively) were inefficient at inducing sterile protection as challenged mice developed parasitemia at the same magnitude as the control mice, which received WT PbANKA SPZ only. The gene discussed is IL6; the disease is parasitic infectious disease.