For this, different groups of mice were infected with IL-6 Tg-PbANKA/LISP2 SPZ using either 104 SPZ (group 1) or 5 x 104 SPZ (group 2) followed by a challenge with 104 WT PbANKA SPZ at day 30 post-infection with IL-6 Tg parasites (Figure 5A). The gene discussed is IL6; the disease is infection.