As shown in Figure 6B, mice that were infected with 104 IL-6 Tg-PbANKA/LISP2 SPZ (group 1) not only did not show any parasitemia after the first and the second infection with the recombinant parasites, as expected, but more interestingly did not develop any parasitemia upon challenge with WT parasites. The gene discussed is IL6; the disease is infection.