Notably, the aforementioned higher rates of clonal evolution in pro-B ALL were almost exclusively linked to the KMT2A subtype (94.4% evolving), while other molecular subtypes with a pro-B ALL immunophenotype were mostly stable, particularly CDX2/UBTF (cases with UBTF::ATXN7L3 gene fusion, only 22.2% evolving and those only in the IGH-DJ library) and ZNF384 (only 30% evolving) (Figure 6A). This evidence concerns the gene CDX2 and acute lymphoblastic leukemia.