Both HMGB, which induces NET formation through a TLR4-dependent manner, and NETosis can be inhibited by targeting extracellular HMGB1 (through glycyrrhizin, a HMGB1 inhibitor) and NETs (through anti DNAse I), where a recent study showed delayed tumor growth post radiotherapy and improved overall survival. This evidence concerns the gene HMGB1 and neoplasm.