MAP3K14 and periodontitis: Based on our previous findings that NIK inhibition is effective for suppressing osteoclast differentiation using aly/aly mice (12, 13) and the NIK inhibitor Cpd33 (14), the present study demonstrated that NIK inhibition is also effective in alveolar bone resorption, even in an experimental periodontitis model, by inhibiting osteoclastogenesis at histological and cellular levels.