NIK-SM1 and NIK inhibitor, 4-(3-((7H-pyrrolo [2,3-d] pyrimidin-4-yl) amino)-4-morpholinophenyl)-2-(thiazol-2-yl) -but-3-yn-2-ol, suppressed alveolar bone resorption in the mouse periodontitis model by inhibiting osteoclast formation and the expression of inflammatory cytokines in the gingiva (28, 29). Here, MAP3K14 is linked to periodontitis.