ZDHHC6‐mediated palmitoylation restrains FLT3‐ITD surface expression, signaling, and colonogenic growth in AML622; intracellular MYD88 palmitoylation by ZDHHC6 is a therapeutic target of sepsis623; ZDHHC6 palmitoylates NRas, contributing to its subcellular localization, and improves the downstream proproliferative signaling cascades in cancers.624. The gene discussed is MYD88; the disease is cancer.