ZDHHC5 plays important role in synaptic plasticity, cardiac function, cell adhesion, and fatty acid uptake; ZDHHC5 interacts with SARS‐CoV‐2 spike protein and affects their subcellular localization and pseudovirus entry621; Circ‐ZDHHC5 accelerates esophageal squamous cell carcinoma progression in vitro.621. This evidence concerns the gene ZDHHC5 and esophageal squamous cell carcinoma.