5‐HT1AR is palmitoylated by ZDHHC21 and reduced 5‐HT1AR palmitoylation is involved in depression665; ZDHHC21 mediates signaling events required for gut hyperpermeability induced by inflammation666; DHHC21 can palmitoylate α1 adrenergic receptor and regulate vascular functions667; DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome.668. This evidence concerns the gene ZDHHC21 and endothelial dysfunction.