Palmitoylation of PD‐L1 by ZDHHC3 inhibits antitumor immunity in vitro613; palmitoylation of ACE2 by ZDHHC3 is critical for the membrane‐targeting of extracellular vesicles secretion614; elevated expression of ZDHHC3 is correlated with poor survival in breast cancer615; high ZDHHC3 levels inhibits synaptic plasticity and memory in high‐fat diet (HFD) mice616; ZDHHC3 regulates the infection of primary and latent herpes simplex Virus 1.617. The gene discussed is CD274; the disease is infection.