ZDHHC18 negatively regulates cGAS‐mediated innate immunity through palmitoylation655; MDH2 palmitoylation by ZDHHC18 sustains mitochondrial respiration and promotes the progress of ovarian cancer656; ZDHHC18 can regulate the cellular plasticity of glioma stem cells and contributes to their survival.657. The gene discussed is MDH2; the disease is central nervous system cancer.