Viral infection enhances the interaction between USP18 and MAVS and promotes the K63‐linked ubiquitination of MAVS to upregulate the production of IFN‐I.882 RNF115 interacts with MAVS to promote K48 ubiquitination of MAVS, and loss of RNF115 enhances antiviral signaling triggered by RNA viruses.883. Here, MAVS is linked to viral infectious disease.