CLDN3 palmitoylated by ZDHHC12 contributes to plasma membrane localization and protein stability of CLDN3, thus promoting the progression of ovarian cancer636; ZDHHC12 can promote the proliferation and migration of glioma cells637; palmitoylation of gephyrin by ZDHHC‐12 contributes to coordinated neurotransmission.638. Here, CLDN3 is linked to central nervous system cancer.