found that phosphorylated PDHE1α (pyruvate dehydrogenase complex E1 subunit α) at S327 by ERK2 in cytoplasm can induce its transfer to mitochondria and improve NF‐κB signal in the cytoplasm, which increases resistance to cytotoxic lymphocytes and promotes tumor immune escape.125. The gene discussed is NFKB1; the disease is neoplasm.