Hyperphosphorylated Tau depolymerizes normal microtubule‐associated proteins after forming neuronfibrillary tangles, disrupts cellular dynamic structures, blocks intracellular material exchange and cell signaling, inhibits ubiquitin (Ub)–proteasome activity, and finally leads to neurodegenerative diseases.190, 191. The gene discussed is MAPT; the disease is neurodegenerative disease.