Kaplan–Meier curves showed that the overexpression of EIF2S1, CAV1, RAN, ANXA5, CYCS, CFL1, MYC, HSP90AA1, PKM, and HSPA5 was significantly associated with a dismal prognosis in the patients with HNSCC. The gene discussed is HSPA5; the disease is head and neck squamous cell carcinoma.