Furthermore, the reduced accumulation of Foxp3+ Treg cells and F4/80+ macrophages, up-regulation of TNFa, IFNg, IL10, down-regulation of IL1, IL6, IL12, TGFb, and decreased release of superoxide, may explain the role of FMT in inhibiting intestinal inflammation and CRC progression. The gene discussed is TGFB1; the disease is colorectal carcinoma.