In comparison with the normal control mice, the protein expressions of IL1a, IL6, IL12a, IL12b, IL17a, TGFb, STAT3, TNFa, IFNg and CXCR4 were significantly elevated in CRC mice, resulting in severe inflammatory responses manifested as hematochezia and lethargy, as well as activation of oncogene transcription. This evidence concerns the gene IL12B and colorectal carcinoma.