HTR1A and Anxiety: Barthas et al.’s (2015) results also confirmed the key role of the excitatory neurons of the ACC in anxiety. Recently, a new study described that regular aerobic exercise had significant effects in relieving pain and concomitant anxiety in the chronic inflammatory pain model. Regular aerobic exercise could increase 5-HT release and attenuate pain-induced LTP occlusion in the ACC through the 5-HT1A and 5-HT7 receptors (Zhou et al., 2022).