CA1 pretreatment could aggravate the neurological deficits, enlarge the infarct volume, exacerbate neuronal damage, worsen the Th17/Treg imbalance, and intensify the inflammatory response, indicating that EP attenuates cerebral ischemia‐reperfusion injury by inhibiting the JAK2/STAT3 signaling pathway. The gene discussed is JAK2; the disease is brain ischemia.