Previous studies demonstrated CD27+IgD+ unswitched memory B cells were innate-like B cells and could produce protective natural IgM in RA [12], whereas CD27−IgD− double negative B cells exacerbated systemic lupus erythematosus (SLE) patients and were linked to renal impairment [13]. The gene discussed is CD27; the disease is systemic lupus erythematosus.