LAG3 and rheumatoid arthritis: As shown in Figure 2, under RA circumstances, LAG3+ B cell frequencies in peripheral blood total B cells (A), naive B cells (B), unswitched memory B cells (C), switched memory B cells (D) and double negative B cells (E) were all down-regulated as compared with healthy individuals and OA patients, despite the reduction in unswitched memory B cells and switched memory B cells was not statistically significant.